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Oxidation of N G ‐hydroxyl‐ l ‐arginine to nitric oxide mediated by respiratory burst: an alternative pathway to NO synthesis
Author(s) -
Modolell Manuel,
Eichmann Klaus,
Soler Germán
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(96)01451-2
Subject(s) - nitric oxide , superoxide , chemistry , respiratory burst , arginine , nitric oxide synthase , biochemistry , metabolite , enzyme , organic chemistry , amino acid
N G ‐Hydroxy‐ l ‐arginine is an intermediate metabolite in the synthesis of nitric oxide that is upregulated and secreted during acute inflammation in vivo. Previous reports have shown that chemically induced superoxide anion oxidizes N G ‐hydroxy‐ l ‐arginine to nitric oxide. Here, we demonstrate that this reaction takes place physiologically in phagocytic cells during the respiratory burst, and is independent of the presence of nitric oxide synthase.