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Overlapping distribution of K ATP channel‐forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain
Author(s) -
Karschin Christine,
Ecke Claudia,
Ashcroft Frances M,
Karschin Andreas
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(96)01438-x
Subject(s) - sulfonylurea receptor , kir6.2 , olfactory bulb , neocortex , protein subunit , biology , cerebellum , in situ hybridization , microbiology and biotechnology , chemistry , biochemistry , messenger rna , neuroscience , central nervous system , gene
ATP‐sensitive K + channels comprise a complex of at least two proteins: a member of the inwardly rectifying Kir6 family (e.g. Kir6.2) and a sulphonylurea receptor (e.g. SUR1) which belongs to the ATP‐binding cassette (ABC) superfamily. Using specific radiolabeled antisense oligonucleotides, the cellular localization of both mRNAs was investigated in the rodent brain by in situ hybridization. The distribution of both transcripts was widespread throughout the brain and showed a high degree of overlap with peak expression levels in the hippocampus, neocortex, olfactory bulb, cerebellum, and several distinct nuclei of the midbrain and brainstem, indicating their important role in vital brain function.