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Expression of a 26S proteasome ATPase subunit, MS73, in muscles that undergo developmentally programmed cell death, and its control by ecdysteroid hormones in the insect Manduca sexta
Author(s) -
Löw P,
Bussell K,
Dawson S.P,
Billett M.A,
Mayer R.J,
Reynolds S.E
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(96)01413-5
Subject(s) - manduca sexta , ecdysteroid , manduca , programmed cell death , biology , moulting , microbiology and biotechnology , proteasome , hormone , endocrinology , protein subunit , insect , medicine , biochemistry , apoptosis , botany , larva , gene
MS73, an ATPase regulatory subunit of the 26S proteasome in the moth Manduca sexta , is shown to be expressed at a high level only in muscles that are undergoing developmentally programmed cell death, or which are destined to do so. The amount of MS73 is increased by more than two‐fold just before death in each of three different muscles that die at different times, under different developmental controls. An ecdysteroid (moulting hormone) agonist, RH‐5849, that prevents the occurrence of programmed cell death in two of these muscles also prevents the normally occurring rise in level of MS73 in these muscles. This evidence is consistent with a role for MS73 in programmed cell death.