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Cloning, expression and CNS distribution of Kv4.3, an A‐type K + channel α subunit
Author(s) -
Tsaur Meei-Ling,
Chou Chaio-Chaio,
Shih Yang-Hsin,
Wang Hung-Li
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(96)01388-9
Subject(s) - neuroscience , hippocampus , thalamus , biology , protein subunit , cerebellum , inferior colliculus , xenopus , complementary dna , genetics , nucleus , gene
A full‐length K + channel cDNA of Kv4.3, with an open reading frame of 611 amino acids, was isolated from rat hippocampus. Functional expression of Kv4.3 cDNA in Xenopus oocytes revealed an A‐type K + channel. In the central nervous system, Kv4.3 is most prominently expressed in the retrosplenial cortex, medial habenula, anterior thalamus, hippocampus, cerebellum, as well as lateral geniculate and superior colliculus, which are important for vision. The abundant expression of Kv4.3 in many CNS neurons supports its important role as a major component of subthreshold A currents in the control of action potentials and thus neuronal excitability.