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The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance
Author(s) -
Miyahara Kohji,
Mizunuma Masaki,
Hirata Dai,
Tsuchiya Eiko,
Miyakawa Tokichi
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(96)01353-1
Subject(s) - saccharomyces cerevisiae , transporter , mutant , multiple drug resistance , atp binding cassette transporter , yeast , biochemistry , efflux , biology , chemistry , gene , antibiotics
The ATP‐binding cassette superfamily proteins Pdr5p and Snq2p of Saccharomyces cerevisiae are implicated in multidrug resistance. Here, we show that these transporters are also involved in cation resistance. Null mutants of PDR5 and SNQ2 genes exhibit increased sensitivity to NaCl, LiCl and MnCl 2 . The mutant cells grown in the presence of high concentrations of these metal salts contain higher levels of the metals than wild‐type cells. The expression of PDR5 and SNQ2 is induced by the metal salts. These results provide evidence that the yeast drug transporters contribute to cation resistance by regulating cellular cation homeostasis under ionic stress conditions.