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Oxidized low‐density lipoprotein induces the production of interleukin‐8 by endothelial cells
Author(s) -
Claise Catherine,
Edeas Marvin,
Chalas Jacqueline,
Cockx Anélie,
Abella Annie,
Capel Liliane,
Lindenbaum Albert
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(96)01255-0
Subject(s) - chemistry , interleukin 1β , production (economics) , interleukin , low density lipoprotein , lipoprotein , microbiology and biotechnology , medicine , endocrinology , biophysics , biochemistry , biology , cytokine , cholesterol , economics , macroeconomics
The concentration of interleukin‐8 (IL‐8) and RANTES was measured in culture supernatants of human EA.hy 926 endothelial cells incubated with oxidized low‐density lipoproteins (LDL). Oxidized LDL induced a 3‐fold increase in IL‐8 production ( p < 0.01), whereas RANTES was not detected. Native LDL did not stimulate IL‐8 production. IL‐8 production in oxidized‐LDL‐treated cells was mediated by reactive oxygen species, as it was partially inhibited by catalase and completely inhibited by glutathione peroxidase and N ‐acetylcysteine ( p < 0.01).