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Evidence for a novel regulatory pathway activated by (carba)prostacyclin in preadipose and adipose cells
Author(s) -
Aubert Jérôme,
Ailhaud Gérard,
Negrel Raymond
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(96)01152-0
Subject(s) - autocrine signalling , paracrine signalling , intracrine , prostacyclin , adipose tissue , microbiology and biotechnology , adipogenesis , receptor , effector , chemistry , biology , endocrinology , biochemistry
Prostacyclin, one of the major prostanoids generated in adipose tissue, has been previously described as an autocrine/ paracrine adipogenic effector, acting, in preadipose cells, by means of cAMP and free Ca 2+ as cell surface receptor‐mediated messengers. The present study presents evidence for the first time that its stable analogue, carbaprostacyclin, is unique among prostanoids in regulating the expression of two differentiation‐dependent genes in preadipose and adipose cells in a way distinct from that elicited by its cell surface receptor. This regulation is likely mediated by some member(s) of the peroxisome proliferator‐activated receptor family and suggests that prostacyclin behaves as an intracrine effector of adipose cell differentiation.