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Alzheimer‐associated presenilin‐2 confers increased sensitivity to poptosis in PC12 cells
Author(s) -
Deng Gangmin,
Pike Christian J.,
Cotman Carl W.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(96)01142-8
Subject(s) - staurosporine , presenilin , viability assay , transfection , microbiology and biotechnology , apoptosis , biology , alzheimer's disease , chemistry , gene , medicine , genetics , disease , kinase , protein kinase c
Presenilin‐2 is a gene of unknown function recently identified based upon linkage with some forms of familial Alzheimer's disease. To investigate potential effects of PS‐2 on cell viability, rat pheochromocytoma (PC12) cells were stably transfected with cDNA constructs encoding either full‐length human PS‐2 or, for comparison, mouse Bcl‐x L . Overexpression of PS‐2 conferred increased sensitivity to the apoptotic stimuli staurosporine and hydrogen peroxide. In contrast, Bcl‐x L overexpression significantly reduced cell death induced by these stimuli. These results suggest that one function of PS‐2 may involve modulation of cell viability.