Premium
The effect of angiostatin on vascular leakage and VEGF expression in rat retina
Author(s) -
Sima Jing,
Zhang Sarah X,
Shao Chunkui,
Fant James,
Ma Jian-xing
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(04)00297-2
Subject(s) - angiostatin , vascular permeability , diabetic retinopathy , vascular endothelial growth factor , retinal , retina , inflammation , vascular endothelial growth factor a , streptozotocin , endocrinology , blockade , medicine , diabetes mellitus , chemistry , biology , angiogenesis , ophthalmology , vegf receptors , receptor , neuroscience
Angiostatin is a potent angiogenic inhibitor. The present study identified a new activity of angiostatin: reducing vascular leakage, which is associated with diabetic macular edema, tumor growth and inflammation. An intravitreal injection of angiostatin significantly reduced retinal vascular permeability in rats with oxygen‐induced retinopathy and in those with streptozotocin‐induced diabetes, but not in normal rats. Consistent with its effect on permeability, angiostatin downregulated vascular endothelial growth factor (VEGF) expression in the retina in both the rat models but not in normal controls. These results suggest that the effect of angiostatin on vascular leakage is mediated, at least in part, through blockade of VEGF overexpression.