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Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures
Author(s) -
Toyomoto Misao,
Ohta Mitsuhiro,
Okumura Kohji,
Yano Hiroe,
Matsumoto Kaori,
Inoue Seiji,
Hayashi Kyozo,
Ikeda Kiyoshi
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(04)00246-7
Subject(s) - nerve growth factor , secretion , medicine , endocrinology , incubation , neurotrophin , astrocyte , neurotrophic factors , neuroprotection , prostaglandin , biology , chemistry , central nervous system , biochemistry , receptor
We found that prostaglandin (PG) D 2 and PGE 2 , which are major PGs in the brain of mammals, powerfully induced the secretion of nerve growth factor (NGF) from cultured mouse astrocytes; PGE 2 or PGD 2 induced an approximately 12‐ or 19‐fold increase in NGF secretion after a 24‐h incubation, respectively. Moreover, it was found that the sequential metabolites of PGD 2 , PGJ 2 , Δ 12 ‐PGJ 2 , and 15‐deoxy‐Δ 12,14 ‐PGJ 2 , induced the NGF secretion to the culture medium strikingly (60–98‐fold of the control after a 24‐h incubation). NGF secretion induced by the J 2 series of PGs was accompanied by the increased expression of NGF mRNA. These PGs also stimulated the secretion/synthesis of brain‐derived neurotrophic factor (BDNF). Our findings suggest that PGs play a neuroprotective role by inducing NGF and BDNF production in the central nervous system.