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The islet‐specific glucose‐6‐phosphatase‐related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane
Author(s) -
Shieh Jeng-Jer,
Pan Chi-Jiunn,
Mansfield Brian C.,
Chou Janice Yang
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(04)00223-6
Subject(s) - endoplasmic reticulum , glycoprotein , subcellular localization , biology , microbiology and biotechnology , proteasome , islet , population , biochemistry , diabetes mellitus , endocrinology , cytoplasm , medicine , environmental health
The islet‐specific glucose‐6‐phosphatase‐related protein (IGRP) has no known catalytic activity, but is of interest because it is the source of the peptide autoantigen targeted by a prevalent population of pathogenic CD8 + T cells in non‐obese diabetic mice. To better understand the potential roles of this protein in diabetes mellitus, we examine the subcellular localization and membrane topography of human IGRP. We show that IGRP is a glycoprotein, held in the endoplasmic reticulum by nine transmembrane domains, which is degraded in cells predominantly through the proteasome pathway that generates the major histocompatibility complex class I‐presented peptides.