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Ceramide‐1‐phosphate: a novel regulator of cell activation
Author(s) -
Gómez-Muñoz Antonio
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(04)00211-x
Subject(s) - ceramide , microbiology and biotechnology , lipid signaling , sphingolipid , phosphorylation , signal transduction , extracellular , sphingomyelin , phospholipase d , kinase , cytosol , intracellular , chemistry , biochemistry , biology , apoptosis , enzyme , membrane
Ceramide‐1‐phosphate (Cer‐1‐P) is emerging as a novel bioactive sphingolipid. It is formed by phosphorylation of ceramide catalyzed by ceramide kinase, and has been implicated in different cellular processes. Cer‐1‐P is mitogenic for fibroblasts, blocks apoptosis in macrophages, controls phagocytosis in neutrophils, and mediates inflammatory responses. Only recently have we started to uncover the signaling pathways that are affected by Cer‐1‐P. Recent work has demonstrated that cytosolic phospholipase A 2 and acid sphingomyelinase are direct intracellular targets of Cer‐1‐P, and that it may also induce phosphorylation of extracellular signal‐regulated kinase‐2 and calcium mobilization. These actions of Cer‐1‐P seem to be cell type‐specific.