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The existence of a putative post‐transcriptional regulatory element in 3′‐UTR of drosophila antibacterial peptide diptericin's mRNA
Author(s) -
Chen Hai-xu,
Li Yue,
Jiang Zhao-zhao,
Qu Xian-ming,
Yang Sheng-li,
Ma Wei-jun
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(04)00161-9
Subject(s) - untranslated region , messenger rna , three prime untranslated region , gene , biology , transcriptional regulation , post transcriptional regulation , regulatory sequence , gene expression , microbiology and biotechnology , genetics
Antibacterial peptides’ genes are rapidly and transiently expressed on immune stimulation, which is the characteristic of immediate early genes. It implies post‐transcriptional regulation is an important pathway in antibacterial peptides’ gene expression. In a search of putative post‐transcriptional regulatory elements, we found a segment of an AU‐rich sequence in 3′‐untranslated region (UTR) of drosophila diptericin mRNA. 3′‐UTR of diptericin mRNA can be specifically bound with Elav and this binding can be competed with the typical AU‐rich element (ARE) of c‐fos mRNA. These results suggest that the AU‐rich sequence in the 3′‐UTR of diptericin mRNA may be a cis ‐acting element and involved in post‐transcriptional regulation.