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Animal deoxyribonucleoside kinases: ‘forward’ and ‘retrograde’ evolution of their substrate specificity 1
Author(s) -
Piškur Jure,
Sandrini Michael P.B,
Knecht Wolfgang,
Munch-Petersen Birgitte
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(04)00081-x
Subject(s) - deoxyribonucleoside , kinase , deoxyribonucleosides , gene duplication , biology , biochemistry , gene , substrate (aquarium) , phosphorylation , substrate specificity , microbiology and biotechnology , enzyme , ecology
Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to study gene duplication and specialisation of the duplicated copies through partitioning of substrate specificity. Recent studies suggest that in the animal lineage one of the progenitor kinases, the so‐called dCK/dGK/TK2‐like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.