Premium
Mono‐unsaturated fatty acids protect against β‐cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure
Author(s) -
Welters Hannah J,
Tadayyon Moh,
Scarpello John H.B,
Smith Stephen A,
Morgan Noel G
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(04)00079-1
Subject(s) - chemistry , apoptosis , cytokine , unsaturated fatty acid , biochemistry , saturated fatty acid , fatty acid , biology , immunology
Long‐chain saturated fatty acids are cytotoxic to pancreatic β‐cells while shorter‐chain saturated and long‐chain unsaturated molecules are better tolerated. Mono‐unsaturated fatty acids are not, however, inert since they inhibit the pro‐apoptotic effects of saturated molecules. In the present work we show that the mono‐unsaturates palmitoleate (C16:1) or oleate (C18:1) also cause marked inhibition of apoptosis induced by exposure of clonal BRIN‐BD11 β‐cells to serum withdrawal or a combination of interleukin‐1β plus interferon‐γ. This response was dose‐dependent and not accompanied by changes in NO formation. Taken together, the results suggest that mono‐unsaturated fatty acids regulate a distal step common to several apoptotic pathways in pancreatic β‐cells.