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Functional properties of soybean nodulin 26 from a comparative three‐dimensional model
Author(s) -
Biswas Sampa
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01529-1
Subject(s) - escherichia coli , aquaporin , aquaporin 1 , chemistry , biophysics , major facilitator superfamily , molecular dynamics , ligand (biochemistry) , molecular model , computational biology , biochemistry , biological system , water channel , biology , transporter , gene , computational chemistry , receptor , mechanical engineering , engineering , inlet
A model of the nodulin 26 channel protein has been constructed based on comparative modeling and molecular dynamics simulations. Structural features of the protein indicate a selectivity filter that differs from those of the known structures of Escherichia coli glycerol facilitator and mammalian aquaporin 1. The model structure also reveals important roles of Ser207 and Phe96 in ligand binding and transport.