Premium
Induction of p53‐independent apoptosis by the BH3‐only protein ITM2Bs
Author(s) -
Fleischer Aarne,
Rebollo Angelita
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01519-9
Subject(s) - puma , apoptosis , programmed cell death , microbiology and biotechnology , p53 protein , suppressor , cell , cell cycle , biology , gene , genetics
The p53 tumor suppressor protein is critically involved in cell cycle regulation and programmed cell death. Here we show that expression of the BH3‐only protein ITM2Bs is able to induce apoptotic cell death in p53+/+, as well as in p53−/− cell lines. This cell death involves neither subcellular redistribution of p53 nor transcriptional regulation of p53 target genes such as Bax, Ras, Puma or Bcl‐2. Together, our data provide evidence for a p53‐independent apoptotic role of ITM2Bs.