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The endoproteolytic processing of αvβ5 integrin is involved in cytoskeleton remodelling and cell migration
Author(s) -
Berthet Virginie,
Rigot Véronique,
Nejjari Mimoun,
Marvaldi Jacques,
Luis José
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01467-4
Subject(s) - integrin , vitronectin , microbiology and biotechnology , cell migration , cytoskeleton , protein subunit , cell adhesion , cleavage (geology) , actin cytoskeleton , chemistry , cell , actin , biology , biochemistry , gene , paleontology , fracture (geology)
We previously showed that the post‐translational cleavage of αv subunit is essential for integrin‐dependent signalling and cell adhesion. Here, we report that blocking αv subunit cleavage by expression of α1‐PDX, a convertase inhibitor, modified the capacity of cells to change shape, via a remodelling of the actin cytoskeleton upon cell attachment. These changes are associated with cell scattering and with a dramatic increase in cell migration to vitronectin. The αv subunit cleavage is thus essential for integrin function and has a considerable impact on integrin‐dependent events, especially those leading to cell migration.