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TRF2 is in neuroglial cytoplasm and induces neurite‐like processes
Author(s) -
Jung Yusun,
Lee Seungku,
Bang Seunghyun,
Kim Soonok,
Choi Kyungho,
Lee Changhee,
Lee Seong-Gene,
Kim Chong Jai,
Song Kyuyoung,
Lee Inchul
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01461-3
Subject(s) - cytoplasm , neurite , microbiology and biotechnology , transfection , retinoic acid , nucleus , chemistry , neuroblastoma , cellular differentiation , biology , in vitro , cell culture , biochemistry , gene , genetics
TRF2 is a ubiquitous protein that protects telomeres in the nucleus. We found that TRF2 was present at the peripheral nerve axons and the brain neuroglial cell processes extensively. It was in the cytoplasmic membrane as well as nuclear fractions, but not in the soluble cytoplasmic fraction of SH‐SY5Y neuroblastoma cells. TRF2 was up‐regulated in P19 embryonal carcinoma cells at the early stage of induced neural differentiation with retinoic acid treatment. Upon transfection, TRF2‐expressing COS cells often produced neurite‐like long cytoplasmic processes. TRF2 is a component of neuroglial cells and appears to be involved in the cytoplasmic process formation that is necessary for neural differentiation.