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Placental growth factor induces FosB and c‐Fos gene expression via Flt‐1 receptors
Author(s) -
Holmes David I.R.,
Zachary Ian
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01452-2
Subject(s) - placental growth factor , fosb , vascular endothelial growth factor , transcription factor , gene expression , biology , growth factor , downregulation and upregulation , medicine , endocrinology , receptor , cancer research , microbiology and biotechnology , gene , vegf receptors , genetics
Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family that binds specifically to Flt‐1. The biological roles of PlGF and Flt‐1 have not yet been defined and the signalling mechanisms mediating cellular actions of PlGF remain poorly understood. In human umbilical vein endothelial cells, VEGF and PlGF induced expression of both full‐length FosB mRNA and an alternatively spliced variant, Δ FosB , with similar efficacy and kinetics. In contrast, PlGF induced c‐ Fos expression less strongly than VEGF, and whereas VEGF strongly upregulated tissue factor mRNA, PlGF had a negligible effect. PlGF induced c‐ Fos expression in porcine aortic endothelial cells specifically expressing Flt‐1, and FosB expression in the monocytic RAW 264.7 cell line expressing endogenous Flt‐1. These findings show for the first time that VEGF and PlGF induce mRNA expression of the transcription factors FosB and c‐Fos, and suggest that these factors may play a role in the biological responses mediated by PlGF and Flt‐1.