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Bone marrow‐derived cells contribute to lung regeneration after elastase‐induced pulmonary emphysema
Author(s) -
Ishizawa Kota,
Kubo Hiroshi,
Yamada Mitsuhiro,
Kobayashi Seiichi,
Numasaki Muneo,
Ueda Shinsaku,
Suzuki Takashi,
Sasaki Hidetada
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01399-1
All‐ trans retinoic acid (ATRA) is known to reverse the anatomic and physiologic signs of pulmonary emphysema. However, the origin of the progenitor cells involved in this lung regeneration remains unclear. Recently, it was shown that bone marrow could be the source of progenitor cells for several cell types. Mice with elastase‐induced emphysema were treated with ATRA, granulocyte colony‐stimulating factor (G‐CSF), or a combination of both. ATRA or G‐CSF promoted lung regeneration and increased bone marrow‐derived cell (BMC) numbers in alveoli. Combined treatment of both had an additive effect, which indicated that BMC mobilization might be important in lung regeneration.