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Fibronectin is a hypoxia‐independent target of the tumor suppressor VHL
Author(s) -
Bluyssen Hans A.R.,
Lolkema Martijn P.J.K.,
van Beest Moniek,
Boone Michelle,
Snijckers Cristel M.J.T.,
Los Maartje,
Gebbink Martijn F.B.G.,
Braam Branko,
Holstege Frank C.P.,
Giles Rachel H.,
Voest Emile E.
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01392-9
Subject(s) - fibronectin , downregulation and upregulation , extracellular matrix , hypoxia (environmental) , suppressor , gene , cancer research , hypoxia inducible factors , biology , tumor suppressor gene , chemistry , microbiology and biotechnology , genetics , carcinogenesis , oxygen , organic chemistry
The von Hippel–Lindau ( VHL ) tumor suppressor gene regulates the extracellular matrix by controlling fibronectin deposition. To identify novel VHL target genes, we subjected mRNA from VHL ‐deficient RCC cells (786‐0‐pRC) and a transfectant re‐expressing wildtype VHL (786‐0‐VHL) to differential expression profiling. Among the differentially expressed genes, we detected that fibronectin is upregulated in the presence of VHL, while it is not affected by hypoxia. Thus regulation of fibronectin deposition by VHL occurs at the transcriptional level, irrespective of oxygen levels.