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Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation
Author(s) -
Hoeks Joris,
Hesselink Matthijs K.C,
van Bilsen Marc,
Schaart Gert,
van der Vusse Ger J,
Saris Wim H.M,
Schrauwen Patrick
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01343-7
Subject(s) - ucp3 , uncoupling protein , peroxisome , downregulation and upregulation , skeletal muscle , biochemistry , chemistry , beta oxidation , fatty acid , peroxisome proliferator activated receptor , medicine , biology , endocrinology , receptor , gene , adipose tissue , brown adipose tissue
We compared UCP3 protein in rat cardiac, glycolytic and oxidative skeletal muscle and examined the effect of high‐fat medium chain vs. long chain triacylglycerol feeding on UCP3 content in these tissues. Cardiac muscle displays the lowest basal levels of UCP3 protein. Increasing long chain – but not medium chain – fatty acid supply upregulates UCP3 in all muscles. Since plasma non‐esterified fatty acids and the expression of two peroxisome proliferator‐activated receptor (PPAR)‐responsive genes, were not different between groups, we conclude that the differential upregulation of UCP3 is not merely PPAR‐mediated. This study supports a role of UCP3 in export of non‐metabolizable fatty acids.