Premium
Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the α‐glucosidase C gene
Author(s) -
Kawabata Yukiko,
Hata Shoji,
Ono Yasuko,
Ito Yoshimasa,
Suzuki Koichi,
Abe Keiko,
Sorimachi Hiroyuki
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01324-3
Subject(s) - calpain , gene , biology , exon , autolysis (biology) , microbiology and biotechnology , genetics , biochemistry , enzyme
There are two classes of an intracellular ‘modulator protease’, calpain: ubiquitous and tissue‐specific. p94/calpain 3 is an example of the latter, predominantly expressed in muscle. A defect in the p94 gene causes muscular dystrophy. Here we report that human and mouse p94 genes have a possible novel alternative promoter expressing p94 variants in all tissues examined including human lens epithelial cells. The possible promoter region and the following novel exons overlap the 3′ region of the neutral α‐glucosidase C gene. Unlike p94, the novel p94 variants expressed in COS7 cells do not undergo rapid autolysis, suggesting basic functions different from p94.