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Systematic search for compact structures of telomeric nucleosomes
Author(s) -
Bešker Neva,
Anselmi Claudio,
Paparcone Raffaella,
Scipioni Anita,
Savino Maria,
De Santis Pasquale
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01193-1
Subject(s) - nucleosome , chromatin , histone , telomere , linker , linker dna , dna , biology , computational biology , genetics , microbiology and biotechnology , biophysics , chemistry , computer science , operating system
Telomeres are structures functionally and structurally distinct from bulk chromatin. They are constituted of highly conserved 5–7 bp tandemly repeated units, organized into nucleosomes with short linkers, whereas the knowledge of the linker histone role in telomeric chromatin is still fragmentary. Experimental evidence suggests the structural organization of telomeric nucleosomes is different from that of the bulk chromatin. This work presents a systematic search of the telomeric nucleosome arrangements. A low‐resolution molecular model was used to evaluate the relative nucleosome packing energy. Structures with favorable energy were found, reducing the possible telomeric chromatin conformations to two different three‐dimensional folds.