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Involvement of gicerin, a cell adhesion molecule, in development and regeneration of chick sciatic nerve
Author(s) -
Hiroi Satoshi,
Tsukamoto Yasuhiro,
Sasaki Fumihiko,
Miki Naomasa,
Taira Eiichi
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01176-1
Subject(s) - sciatic nerve , dorsal root ganglion , regeneration (biology) , neurite , spinal cord , cell adhesion molecule , anatomy , sciatic nerve injury , microbiology and biotechnology , biology , neuroscience , in vitro , biochemistry
We have examined the role of gicerin, an immunoglobulin superfamily cell adhesion molecule, in chick sciatic nerves during development and regeneration. Gicerin was expressed in the spinal cord, dorsal root ganglion (DRG) and sciatic nerves in embryos, but declined after hatching. Neurite extensions from explant cultures of the DRG were promoted on gicerin's ligands, which were inhibited by an anti‐gicerin antibody. Furthermore, gicerin expression was upregulated in the regenerating sciatic nerves, DRG and dorsal horn of the spinal cord after injury to the sciatic nerve. These results indicate that gicerin might participate in the development and regeneration of sciatic nerves.