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The Wilms’ tumour suppressor protein, WT1, undergoes CRM1‐independent nucleocytoplasmic shuttling
Author(s) -
Vajjhala P.R,
Macmillan E,
Gonda T,
Little M
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01144-x
Subject(s) - zinc finger , suppressor , transcription factor , biology , nuclear export signal , cancer research , microbiology and biotechnology , nuclear protein , transcription (linguistics) , gene , cell nucleus , genetics , linguistics , philosophy
The Wilms’ tumour suppressor gene (WT1) encodes a zinc finger‐containing nuclear protein essential for kidney and urogenital development. Initially considered a transcription factor, there is mounting evidence that WT1 has a role in post‐transcriptional processing. Using the interspecies heterokaryon assay, we have demonstrated that WT1 can undergo nucleocytoplasmic shuttling. We have also mapped the region responsible for nuclear export to residues 182–324. Our data add further complexity to the role of WT1 in trancriptional and post‐transcriptional regulation.