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Physical and functional interaction of the Werner syndrome protein with poly‐ADP ribosyl transferase
Author(s) -
Adelfalk Caroline,
Kontou Maria,
Hirsch-Kauffmann Monica,
Schweiger Manfred
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01088-3
Subject(s) - helicase , werner syndrome , dna repair , transferase , dna replication , premature aging , dna , biology , genetics , gene , microbiology and biotechnology , chemistry , biochemistry , enzyme , rna
Werner's syndrome is a rare disease of premature ageing. The WRN gene product defective in this disorder belongs to the RecQ helicase family and is thought to be involved in DNA metabolism. Another protein, which plays an important role in both DNA replication and repair, is the poly‐ADP ribosyl transferase. Here we demonstrate an interaction of these two proteins resulting in ADP‐ribosylation of the WRN protein. These results imply that WRN is involved in DNA replication and in DNA repair.