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T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK 1
Author(s) -
Dadgostar Hajir,
Doyle Sean E.,
Shahangian Arash,
Garcia Daniel E.,
Cheng Genhong
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)01072-x
Subject(s) - signal transducing adaptor protein , microbiology and biotechnology , signal transduction , subcellular localization , kinase , biology , chemistry , cytoplasm
Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)‐associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3‐associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3‐interacting Jun N‐terminal kinase (JNK)‐activating modulator). This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent‐insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)‐κB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3‐mediated JNK activation.