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Is there an evolutionary relationship between WARP (von Willebrand factor A‐domain‐related protein) and the FACIT and FACIT‐like collagens?
Author(s) -
Fitzgerald Jamie,
Bateman John F.
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00968-2
Subject(s) - triple helix , domain (mathematical analysis) , von willebrand factor , biology , protein domain , genetics , evolutionary biology , gene , immunology , mathematical analysis , platelet , mathematics
We suggest that there is an evolutionary relationship between von Willebrand factor A‐domain‐related protein (WARP), and the fibril‐associated collagen with interrupted triple helix (FACIT) and FACIT‐like subfamilies of collagens. Data from a comparison of amino acid sequences, domain organisation and chromosomal location are consistent with the hypothesis that WARP and these collagens share a common collagen ancestor. In support of this is the observation that the WARP 3′ coding region is GC‐rich suggesting that this may represent the remnant of a triple helix protein domain which WARP has ‘lost’ during evolution.