Premium
Adenovirus 2 E1B‐55K protein relieves p53‐mediated transcriptional repression of the survivin and MAP4 promoters
Author(s) -
Punga Tanel,
Akusjärvi Göran
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00927-x
Subject(s) - promoter , repressor , corepressor , psychological repression , microbiology and biotechnology , survivin , chemistry , retinoblastoma like protein 1 , activator (genetics) , transcription (linguistics) , adenoviridae , cancer research , biology , gene , transcription factor , recombinant dna , gene expression , biochemistry , linguistics , philosophy
It is well established that adenovirus E1B‐55K protein functions as an inhibitor of the tumor suppressor protein p53 by binding and inactivating p53 as a transcriptional activator protein. Here we show that the adenovirus 2 E1B‐55K protein also blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters. The repression is dependent on the ability of E1B‐55K to bind to p53 and is enhanced by coexpression of the adenovirus E4orf6 protein. Overexpression of the transcriptional corepressor protein Sin3A partially relieves the inhibitory effect of E1B‐55K, suggesting that E1B‐55K blocks p53 functions by interfering with the Sin3 complex.