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How often does the myristoylated N‐terminal latch of c‐Abl come off?
Author(s) -
Zhou Huan-Xiang
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00911-6
Subject(s) - myristoylation , terminal (telecommunication) , abl , dissociation (chemistry) , chemistry , proto oncogene tyrosine protein kinase src , tyrosine kinase , kinase , phosphorylation , biochemistry , signal transduction , computer science , computer network , organic chemistry
The myristoylated N‐terminal latching to the C‐terminal lobe of c‐Abl was recently demonstrated to be an important regulatory element for the kinase, playing a role similar to that of the tyrosine‐phosphorylated C‐terminal tail of c‐Src. A potential mechanism for activating c‐Abl is the dissociation of the myristoylated N‐terminal latch. How often does this latch spontaneously come off? A recent theoretical model along with the experimental results of Superti‐Furga, Kuriyan, and co‐workers suggests that the equilibrium fraction of c‐Abl in which the myristoylated N‐terminal is unlatched is ∼0.5%.