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2‐Cyclopenten‐1‐one and prostaglandin J 2 reduce restenosis after balloon angioplasty in rats: role of NF‐κB
Author(s) -
Ianaro Angela,
Maffia Pasquale,
Cuzzocrea Salvatore,
Mazzon Elena,
Santoro Maria Gabriella,
Di Rosa Massimo,
Ialenti Armando
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00873-1
Subject(s) - restenosis , balloon , angioplasty , medicine , nf κb , cardiology , carotid arteries , prostaglandin , endocrinology , stent , inflammation
The aim of this study was to evaluate, using a rat model of balloon angioplasty, whether prostaglandin (PG) J 2 and 2‐cyclopenten‐1‐one are able to reduce restenosis. We found that both PGJ 2 and 2‐cyclopenten‐1‐one, administered by local application on carotid arteries, caused a dose‐dependent inhibition of neointimal formation. Furthermore, both agents prevented vascular negative remodeling. The effect of these compounds on restenosis was correlated with an inhibition of nuclear factor‐κB (NF‐κB) activation as well as of intercellular adhesion molecule‐1 (ICAM‐1) protein expression in injured carotid arteries of control animals. Our results show that cyclopentenone PGs and their derivatives reduce restenosis and may have therapeutic relevance for the prevention of human restenosis.