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Global analysis of G‐protein‐coupled receptor signaling in human tissues
Author(s) -
Hakak Yaron,
Shrestha Devin,
Goegel Moira C.,
Behan Dominic P.,
Chalmers Derek T.
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00762-2
Subject(s) - g protein coupled receptor , signal transduction , receptor , biology , cell signaling , microbiology and biotechnology , gene , computational biology , gene expression , gene expression profiling , genetics
The G‐protein‐coupled receptor (GPCR) family mediates a host of cell–cell communications upon activation by diverse ligands. Numerous GPCRs have been shown to display anatomically selective patterns of gene expression, however, our understanding of the complexity of GPCR signaling within human tissues remains unclear. In an effort to characterize global patterns of GPCR signaling in the human body, microarray analysis was performed on a large panel of tissues to monitor the gene expression levels of the receptors as well as related signaling and regulatory molecules. Analysis of the data revealed complex signaling networks in many tissue types, with tissue‐specific patterns of gene expression observed for the majority of the receptors and a number of components and regulators of GPCR signaling.