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LKB1, a protein kinase regulating cell proliferation and polarity
Author(s) -
Boudeau Jérôme,
Sapkota Gopal,
Alessi Dario R.
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00642-2
Subject(s) - kinase , prenylation , cell polarity , suppressor , protein kinase a , phosphorylation , biology , microbiology and biotechnology , cell growth , polarity (international relations) , signal transduction , serine , cell , cancer research , cancer , computational biology , genetics , biochemistry , enzyme
LKB1 is a serine‐threonine protein kinase mutated in patients with an autosomal dominantly inherited cancer syndrome predisposing to multiple benign and malignant tumours, termed Peutz–Jeghers syndrome. Since its discovery in 1998, much research has focused on identification and characterisation of its cellular roles and analysing how LKB1 might be regulated. In this review we discuss exciting recent advances indicating that LKB1 functions as a tumour suppressor perhaps by controlling cell polarity. We also outline the current understanding of the molecular mechanisms by which LKB1 is regulated in vivo, through interaction with other proteins as well as by protein phosphorylation and prenylation.