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Association of liver steatosis with lipid oversecretion and hypotriglyceridaemia in C57BL/6j mice fed trans ‐10, cis ‐12‐linoleic acid
Author(s) -
Degrace Pascal,
Demizieux Laurent,
Gresti Joseph,
Chardigny Jean-Michel,
Sébédio Jean-Louis,
Clouet Pierre
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00610-0
Subject(s) - steatosis , linoleic acid , medicine , liver steatosis , biology , fatty liver , fatty acid , biochemistry , disease
Conjugated linoleic acids (CLA) have recently been recognized to reduce body fat and plasma lipids in some animals. This study demonstrated that the steatosis accompanying the fat loss induced by trans ‐10, cis ‐12‐C 18:2 (CLA2) and not cis ‐9, trans ‐11‐C 18:2 (CLA1) isomer in C57BL/6j mice was not due to an alteration of the liver lipoprotein production that was even increased. The 3‐fold decrease in plasma triacylglycerol contents and the induction of mRNA expression of low‐density lipoprotein receptors concomitantly observed in CLA2‐fed mice suggested an increase in the lipoprotein clearance at the level of the liver itself. CLA1 feeding produced similar but attenuated effects on triglyceridaemia only.