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New intracellular components of bone morphogenetic protein/Smad signaling cascades
Author(s) -
Zwijsen An,
Verschueren Kristin,
Huylebroeck Danny
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00566-0
Subject(s) - smad , bone morphogenetic protein , bone morphogenetic protein 2 , intracellular , microbiology and biotechnology , chemistry , bone morphogenetic protein 5 , bmpr2 , bone morphogenetic protein 7 , signal transduction , bone morphogenetic protein 10 , biology , biochemistry , in vitro , gene
Bone morphogenetic proteins (BMPs) regulate many processes in the embryo, including cell type specification, patterning, apoptosis, and epithelial–mesenchymal interaction. They also act in soft and hard tissues in adult life. Their signals are transduced from the plasma membrane to the nucleus through a limited number of Smad proteins. The list of Smad‐interacting proteins is however growing and it is clear that these partners determine the outcome of the signal. We summarize the present status in BMP/Smad signaling, with emphasis on recently identified Smad partners and how these proteins may cooperate in the regulation of the expression of BMP target genes.