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Search for new cyclic AMP‐binding proteins
Author(s) -
Dremier S.,
Kopperud R.,
Doskeland S.O.,
Dumont J.E.,
Maenhaut C.
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00561-1
Subject(s) - creb1 , protein kinase a , intracellular , nucleotide , cyclic nucleotide , biochemistry , dna binding protein , microbiology and biotechnology , biology , g protein , chemistry , receptor , kinase , transcription factor , gene , creb
Today, there is evidence that the cAMP‐dependent kinases (PKA) are not the only intracellular receptors involved in intracellular cAMP signalling in eukaryotes. Other cAMP‐binding proteins have been recently identified, including some cyclic nucleotide‐gated channels and Epac (exchange protein directly activated by cAMP) proteins. All these proteins bind cAMP through conserved cyclic nucleotide monophosphate‐binding domains. However, all putative cAMP‐binding proteins having such domains, as revealed by computer analysis, do not necessarily bind cAMP, indicating that their presence is not a sufficient criteria to predict cAMP‐binding property for a protein.