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Measles virus V protein blocks interferon (IFN)‐α/β but not IFN‐γ signaling by inhibiting STAT1 and STAT2 phosphorylation
Author(s) -
Takeuchi Kaoru,
Kadota Shin-ich,
Takeda Makoto,
Miyajima Naoko,
Nagata Kyosuke
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00528-3
Subject(s) - stat2 , stat1 , measles virus , tyrosine phosphorylation , phosphorylation , interferon , microbiology and biotechnology , tyrosine , protein phosphorylation , signal transduction , hela , biology , stat protein , chemistry , virology , biochemistry , cell , stat3 , protein kinase a , measles , vaccination
Measles virus (MV), a member of the family Paramyxoviridae, encodes C and V non‐structural proteins. To clarify the functions of MV C and V proteins, HeLa cell lines constitutively expressing C or V protein were established. We found that expression of V protein inhibited interferon (IFN)‐α/β signaling but not IFN‐γ signaling. C protein had no inhibitory effect on IFN signaling in our experimental condition. Degradation of selective signal transducers and activators of transcription (STAT) proteins was not observed in HeLa cells expressing V protein. In contrast, tyrosine phosphorylation of both STAT1 and STAT2 was inhibited in these cells after IFN‐β stimulation.