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Metabolic efficiency of liver mitochondria in rats with decreased thermogenesis
Author(s) -
Iossa Susanna,
Mollica Maria Pia,
Lionetti Lillà,
Crescenzo Raffaella,
Botta Monica,
Liverini Giovanna
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00490-3
Subject(s) - thermogenesis , medicine , endocrinology , triiodothyronine , basal metabolic rate , basal (medicine) , chemistry , mitochondrion , biology , adipose tissue , biochemistry , thyroid , insulin
We have studied changes in hepatic mitochondrial efficiency induced by 24‐h fasting or acclimation at 29°C, two conditions of reduced thermogenesis. Basal and palmitate‐induced proton leak, which contribute to mitochondrial efficiency, are not affected after 24‐h fasting, when serum free triiodothyronine decreases significantly and serum free fatty acids increase significantly. In rats at 29°C, in which serum free triiodothyronine and fatty acids decrease significantly, basal proton leak increases significantly, while no variation is found in palmitate‐induced proton leak. The present results indicate that mitochondrial efficiency in the liver is not related to a physiological decrease in whole body thermogenesis.