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Protein kinase D: a family affair
Author(s) -
Rykx An,
De Kimpe Line,
Mikhalap Svetlana,
Vantus Tibor,
Seufferlein Thomas,
Vandenheede Jackie R.,
Van Lint Johan
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00487-3
Subject(s) - microbiology and biotechnology , golgi apparatus , enzyme , kinase , biology , pkd1 , protein kinase a , gene isoform , function (biology) , biochemistry , chemistry , genetics , gene , endoplasmic reticulum , polycystic kidney disease , kidney
The protein kinase D family of enzymes consists of three isoforms: PKD1/PKCμ, PKD2 and PKD3/PKCν. They all share a similar architecture with regulatory sub‐domains that play specific roles in the activation, translocation and function of the enzymes. The PKD enzymes have recently been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation.