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Identification and analysis of catalytic TIM barrel domains in seven further glycoside hydrolase families
Author(s) -
Rigden Daniel J,
Jedrzejas Mark J,
de Mello Luciane V
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00481-2
Subject(s) - glycoside hydrolase , triosephosphate isomerase , catalysis , hydrolase , chemistry , biochemistry , biology , domain (mathematical analysis) , enzyme , stereochemistry , mathematical analysis , mathematics
Fold recognition results allocate catalytic triose phosphate isomerase (TIM) barrels to seven previously unassigned glycoside hydrolase (GH) families, numbers 29, 44, 50, 71, 84, 85 and 89, enabling prediction of catalytic residues. Modelling of GH family 50 suggests that it may be the common evolutionary ancestor of families 42 and 14. TIM barrels now comprise the catalytic domains of more than half of the assigned GH families, and catalyse a much larger variety of GH reactions than any other catalytic domain architecture. Only 327 GH sequences still have no structurally identified catalytic domain.