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The ‘magic tail’ of G protein‐coupled receptors: an anchorage for functional protein networks
Author(s) -
Bockaert Joël,
Marin Philippe,
Dumuis Aline,
Fagni Laurent
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00453-8
Subject(s) - g protein coupled receptor , allosteric regulation , computational biology , receptor , signal transduction , biology , proteomics , microbiology and biotechnology , biochemistry , gene
All cell types express a great variety of G protein‐coupled receptors (GPCRs) that are coupled to only a limited set of G proteins. This disposition favors cross‐talk between transduction pathways. However, GPCRs are organized into functional units. They promote specificity and thus avoid unsuitable cross‐talk. New methodologies (mostly yeast two‐hybrid screens and proteomics) have been used to discover more than 50 GPCR‐associated proteins that are involved in building these units. In addition, these protein networks participate in the trafficking, targeting, signaling, fine‐tuning and allosteric regulation of GPCRs. To date, proteins that interact with the GPCR C‐terminus are the most abundant and are the focus of this review.