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The human G protein β4 subunit: gene structure, expression, Gγ and effector interaction
Author(s) -
Rosskopf Dieter,
Nikula Christiane,
Manthey Iris,
Joisten Markus,
Frey Ulrich,
Kohnen Stefanie,
Siffert Winfried
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00441-1
Subject(s) - heterotrimeric g protein , protein subunit , gene , g protein , effector , biology , translation (biology) , genetics , chemistry , microbiology and biotechnology , signal transduction , messenger rna
The aim of this study was the characterization of the human Gβ4 subunit of heterotrimeric G proteins. Human Gβ4 is widely expressed. Its gene is located on chromosome 3 with a genomic structure indistinguishable from that of the genes of Gβ1 to Gβ3, but entirely different from Gβ5. In vitro translation co‐precipitation analyses revealed that Gβ4 can form stable dimers with Gγ1, Gγ2, Gγ3, Gγ4, Gγ5, Gγ7, Gγ10, Gγ11, Gγ12, and Gγ13, dimers which were also able to stimulate phospholipase β2.