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ATP synthesis driven by proton transport in F 1 F 0 ‐ATP synthase
Author(s) -
Weber Joachim,
Senior Alan E
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00394-6
Subject(s) - atp synthase , atp synthase gamma subunit , atp hydrolysis , chemiosmosis , enzyme , protein subunit , rotation (mathematics) , proton , atpase , chemistry , v atpase , f atpase , proton transport , biochemistry , physics , computer science , nuclear physics , thylakoid , chloroplast , artificial intelligence , gene
Topical questions in ATP synthase research are: (1) how do protons cause subunit rotation and how does rotation generate ATP synthesis from ADP+Pi? (2) How does hydrolysis of ATP generate subunit rotation and how does rotation bring about uphill transport of protons? The finding that ATP synthase is not just an enzyme but rather a unique nanomotor is attracting a diverse group of researchers keen to find answers. Here we review the most recent work on rapidly developing areas within the field and present proposals for enzymatic and mechanoenzymatic mechanisms.