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IQGAP1 as signal integrator: Ca 2+ , calmodulin, Cdc42 and the cytoskeleton
Author(s) -
Briggs Michael W,
Sacks David B
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00333-8
Subject(s) - iqgap1 , microbiology and biotechnology , cytoskeleton , microtubule , scaffold protein , calmodulin , signal transducing adaptor protein , calmodulin binding proteins , actin cytoskeleton , biology , cdc42 , signal transduction , gtpase , chemistry , cell , biochemistry , enzyme
A family of proteins known as IQGAPs have been identified in yeast, amebas and mammals. IQGAPs are multidomain molecules that contain several protein‐interacting motifs which mediate binding to target proteins. Mammalian IQGAP1 is a component of signaling networks that are integral to maintaining cytoskeletal architecture and cell–cell adhesion. Published data suggest that IQGAP1 is a scaffolding protein that modulates cross‐talk among diverse pathways in complex regulatory circuits. These pathways include modulating the actin cytoskeleton, mediating signaling by Rho family GTPases and calmodulin, regulating E‐cadherin and β‐catenin function and organizing microtubules.