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Enhanced plasma ghrelin levels in rats with streptozotocin‐induced diabetes
Author(s) -
Masaoka Tatsuhiro,
Suzuki Hidekazu,
Hosoda Hiroshi,
Ota Takayuki,
Minegishi Yuriko,
Nagata Hiroshi,
Kangawa Kenji,
Ishii Hiromasa
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00306-5
Subject(s) - ghrelin , endocrinology , medicine , streptozotocin , secretion , diabetes mellitus , hormone , chemistry
Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin‐induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.