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Gene expression patterns define pathways correlated with loss of differentiation in lung adenocarcinomas
Author(s) -
Creighton Chad,
Hanash Samir,
Beer David
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00259-x
Subject(s) - kegg , pyrimidine metabolism , biology , gene , purine metabolism , microarray analysis techniques , cellular differentiation , gene expression , microarray , metabolism , gene expression profiling , cell growth , biochemistry , purine , microbiology and biotechnology , transcriptome , enzyme
An analysis of microarray data from 86 lung adenocarcinomas reveals hundreds of genes significantly correlated with tumor cell differentiation. A bioinformatics approach of linking these genes to public information from the Locuslink and KEGG databases yields evidence for a loss of tumor cell differentiation being associated with biological processes of cell division, protein degradation, pyrimidine and purine metabolism, oxidative phosphorylation, glyoxylate and dicarboxylate metabolism, folate biosynthesis, and glutamate metabolism. The increased expression of genes involved in these processes is consistent with increased proliferation and metabolism characteristics of poorly differentiated tumors. The complete results of this analysis are available at http://dot.ped.med.umich.edu:2000/pub/diff/index.htm.