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The dual role of protein kinase C in the regulation of telomerase activity in human lymphocytes
Author(s) -
Sheng Wei-Yun,
Chien Ya-Li,
Wang Tzu-Chien V
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00230-8
Subject(s) - telomerase , protein kinase c , telomerase reverse transcriptase , downregulation and upregulation , microbiology and biotechnology , telomere , biology , function (biology) , enzyme , kinase , enzyme activator , chemistry , biochemistry , signal transduction , gene
Protein kinase C (PKC) has been implicated to play an essential function in the upregulation of telomerase activity in activated T cells, yet its role in the regulation of telomerase activity remains largely unknown. In this work, we present evidence that PKC activity is required both for the induction of hTERT expression and for the post‐transcriptional control of telomerase enzyme activity in T lymphocytes. Of the several PKC isoforms present in lymphocytes, only the level of PKC‐ζ was greatly increased during T cell activation, implicating that PKC‐ζ may be required for the post‐transcriptional control of telomerase enzyme activity in T lymphocytes.