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Identification of mammalian orthologs associates PYPAF5 with distinct functional roles
Author(s) -
Albrecht Mario,
Domingues Francisco S.,
Schreiber Stefan,
Lengauer Thomas
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00161-3
Subject(s) - pyrin domain , biology , regulator , gene , nod1 , nod2 , microbiology and biotechnology , receptor , genetics , inflammasome , computational biology , identification (biology) , innate immune system , botany
PYRIN‐ and CARD‐containing proteins belong to a recently identified protein family involved in the regulation of apoptosis and inflammatory processes. Variations in the gene products of the family members PYPAF1 and NOD2/CARD15 have been associated with several autoinflammatory diseases. We could identify the mouse orthologs of PYPAF1, PYPAF5, NOD1, NOD2 and the rat ortholog of PYPAF5. Intriguingly, we found that PYPAF5 has been reported previously not only as regulator of NF‐κB and caspase‐1, but also as angiotensin II and vasopressin receptor. In particular, based on a comprehensive sequence analysis, we propose a structural model for this hormone receptor that is different from the model suggested previously.